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Lebers atrophy (degeneration of the optic nerve resulting in loss of central vision)
If these develop while taking supplements, they warrant medical assessment to rule out ongoing deficiency or other neurological conditions
They are generally considered for young people with obesity, which is associated with increased risks of health problems like type 2 diabetes, high blood pressure, and heart disease
As an example, immunopathologic vasculopathy in a hypoxic model of pulmonary hypertension was found to be driven by G6PD-induced pro-inflammatory epigenetic signaling including upregulated expression of pro-inflammatory factors (e.g., tumor necrosis factor-alpha [TNF-]), increased numbers of activated macrophages, and activated platelets and conversely, was able to be mitigated with G6PD deficiency ( G6PD-dependent ROS generation is also important in innate immune sensing by macrophages ( Figure 1B-1 )
[PMC free article: PMC296557] [PubMed: 2318976] 732
